Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring

Henriikka Salomäki; Merja Heinäniemi; Laura H. Vähätalo; Liisa Ailanen; Kim Eerola; Suvi T. Ruohonen; Ullamari Pesonen; Markku Koulu

doi:10.1371/journal.pone.0115778

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Open Access

Peer-reviewed

Research Article

Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring

Henriikka Salomäki,

Affiliations Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland, Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland
⨯
Merja Heinäniemi,

Affiliation School of Medicine, Institute of Biomedicine, University of Eastern Finland, FI-70211 Kuopio, Finland
⨯
Laura H. Vähätalo,

Affiliations Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland, Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland, Turku Center for Disease Modeling (TCDM), University of Turku, FI-20014 Turku, Finland
⨯
Liisa Ailanen,

Affiliations Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland, Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland, Turku Center for Disease Modeling (TCDM), University of Turku, FI-20014 Turku, Finland
⨯
Kim Eerola,

Affiliations Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland, Drug Research Doctoral Programme (DRDP), University of Turku, Turku, Finland, Turku Center for Disease Modeling (TCDM), University of Turku, FI-20014 Turku, Finland
⨯
Suvi T. Ruohonen,

Affiliations Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland, Turku Center for Disease Modeling (TCDM), University of Turku, FI-20014 Turku, Finland
⨯
Ullamari Pesonen,

Affiliation Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland
⨯
Markku Koulu

* E-mail: markku.koulu@utu.fi

Affiliation Department of Pharmacology, Drug Development and Therapeutics, Institute of Biomedicine, University of Turku, FI-20014 Turku, Finland
⨯

Prenatal Metformin Exposure in a Maternal High Fat Diet Mouse Model Alters the Transcriptome and Modifies the Metabolic Responses of the Offspring

Henriikka Salomäki,
Merja Heinäniemi,
Laura H. Vähätalo,
Liisa Ailanen,
Kim Eerola,
Suvi T. Ruohonen,
Ullamari Pesonen,
Markku Koulu

Published: December 26, 2014
https://doi.org/10.1371/journal.pone.0115778

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