Carriers of Loss-of-Function Mutations in EXT Display Impaired Pancreatic Beta-Cell Reserve Due to Smaller Pancreas Volume

Sophie J. Bernelot Moens; Hans L. Mooij; H . Carlijne Hassing; Janine K. Kruit; Julia J. Witjes; Michiel A. J. van de Sande; Aart J. Nederveen; Ding Xu; Geesje M. Dallinga-Thie; Jeffrey D. Esko; Erik S. G. Stroes; Max Nieuwdorp

doi:10.1371/journal.pone.0115662

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Open Access

Peer-reviewed

Research Article

Carriers of Loss-of-Function Mutations in EXT Display Impaired Pancreatic Beta-Cell Reserve Due to Smaller Pancreas Volume

Sophie J. Bernelot Moens ,

Contributed equally to this work with: Sophie J. Bernelot Moens, Hans L. Mooij

Affiliation Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯
Hans L. Mooij ,

Contributed equally to this work with: Sophie J. Bernelot Moens, Hans L. Mooij

Affiliation Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯
H . Carlijne Hassing,

Affiliation Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯
Janine K. Kruit,

Affiliation Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands
⨯
Julia J. Witjes,

Affiliation Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯
Michiel A. J. van de Sande,

Affiliation Department of Orthopaedics, LUMC, Leiden, the Netherlands
⨯
Aart J. Nederveen,

Affiliation Department of Radiology, Academic Medical Center, Amsterdam, the Netherlands
⨯
Ding Xu,

Affiliation Department of Cellular and Molecular Medicine, UC San Diego, San Diego, California, United States of America
⨯
Geesje M. Dallinga-Thie,

Affiliations Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands, Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯
Jeffrey D. Esko,

Affiliation Department of Cellular and Molecular Medicine, UC San Diego, San Diego, California, United States of America
⨯
Erik S. G. Stroes,

Affiliation Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯
Max Nieuwdorp

* E-mail: m.nieuwdorp@amc.uva.nl

Affiliations Department of Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands, Department of Cellular and Molecular Medicine, UC San Diego, San Diego, California, United States of America, Department of Experimental Vascular Medicine, Academic Medical Center, Amsterdam, the Netherlands
⨯

Carriers of Loss-of-Function Mutations in EXT Display Impaired Pancreatic Beta-Cell Reserve Due to Smaller Pancreas Volume

Sophie J. Bernelot Moens,
Hans L. Mooij,
H . Carlijne Hassing,
Janine K. Kruit,
Julia J. Witjes,
Michiel A. J. van de Sande,
Aart J. Nederveen,
Ding Xu,
Geesje M. Dallinga-Thie,
Jeffrey D. Esko

Published: December 26, 2014
https://doi.org/10.1371/journal.pone.0115662

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