Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Jun Lu; Heming Wei; Jianjun Wu; Mohd Fadzly Amar Jamil; Mei Lan Tan; Mohd Ilham Adenan; Philip Wong; Winston Shim

doi:10.1371/journal.pone.0115648

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Open Access

Peer-reviewed

Research Article

Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Jun Lu ,

Contributed equally to this work with: Jun Lu, Heming Wei

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Republic of Singapore
⨯
Heming Wei ,

Contributed equally to this work with: Jun Lu, Heming Wei

Affiliations National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Republic of Singapore, Cardiovascular & Metabolic Disorders Program, DUKE-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore
⨯
Jianjun Wu,

Affiliation National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Republic of Singapore
⨯
Mohd Fadzly Amar Jamil,

Affiliation Advanced Medical and Dental Institute, Universiti Sains Malaysia, Pulau Pinang, Malaysia
⨯
Mei Lan Tan ,

* E-mail: winston.shim.s.n@nhcs.com.sg (WS); tanml@usm.my (MLT)

Affiliations Malaysian Institute of Pharmaceuticals & Nutraceuticals. Ministry of Science, Technology & Innovation (MOSTI), Pulau Pinang, Malaysia, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Pulau Pinang, Malaysia
⨯
Mohd Ilham Adenan,

Affiliation Malaysian Institute of Pharmaceuticals & Nutraceuticals. Ministry of Science, Technology & Innovation (MOSTI), Pulau Pinang, Malaysia
⨯
Philip Wong,

Affiliations National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Republic of Singapore, Cardiovascular & Metabolic Disorders Program, DUKE-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore
⨯
Winston Shim

* E-mail: winston.shim.s.n@nhcs.com.sg (WS); tanml@usm.my (MLT)

Affiliations National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Republic of Singapore, Cardiovascular & Metabolic Disorders Program, DUKE-NUS Graduate Medical School Singapore, Singapore, Republic of Singapore
⨯

Evaluation of the Cardiotoxicity of Mitragynine and Its Analogues Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Jun Lu,
Heming Wei,
Jianjun Wu,
Mohd Fadzly Amar Jamil,
Mei Lan Tan,
Mohd Ilham Adenan,
Philip Wong,
Winston Shim

Published: December 23, 2014
https://doi.org/10.1371/journal.pone.0115648

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