Detection of Methylated Septin 9 in Tissue and Plasma of Colorectal Patients with Neoplasia and the Relationship to the Amount of Circulating Cell-Free DNA

Kinga Tóth; Reinhold Wasserkort; Ferenc Sipos; Alexandra Kalmár; Barnabás Wichmann; Katalin Leiszter; Gábor Valcz; Márk Juhász; Pál Miheller; Árpád V. Patai; Zsolt Tulassay; Béla Molnár

doi:10.1371/journal.pone.0115415

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Open Access

Peer-reviewed

Research Article

Detection of Methylated Septin 9 in Tissue and Plasma of Colorectal Patients with Neoplasia and the Relationship to the Amount of Circulating Cell-Free DNA

Kinga Tóth ,

Contributed equally to this work with: Kinga Tóth, Reinhold Wasserkort

* E-mail: drtothkinga@yahoo.com

Affiliation 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⨯
Reinhold Wasserkort ,

Contributed equally to this work with: Kinga Tóth, Reinhold Wasserkort

Current address: Fraunhofer Institute of Cell Therapy and Immunology, Extracorporeal Immunomodulation Unit, Rostock, Germany

Affiliation Epigenomics AG, Berlin, Germany
⨯
Ferenc Sipos,

Affiliation 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⨯
Alexandra Kalmár,

Affiliations 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary, Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
⨯
Barnabás Wichmann,

Affiliation Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
⨯
Katalin Leiszter,

Affiliation 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⨯
Gábor Valcz,

Affiliation Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
⨯
Márk Juhász,

Affiliation 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⨯
Pál Miheller,

Affiliation 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⨯
Árpád V. Patai,

Affiliation 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
⨯
Zsolt Tulassay,

Affiliations 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary, Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
⨯
Béla Molnár

Affiliations 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary, Molecular Medicine Research Unit, Hungarian Academy of Sciences, Budapest, Hungary
⨯

Detection of Methylated Septin 9 in Tissue and Plasma of Colorectal Patients with Neoplasia and the Relationship to the Amount of Circulating Cell-Free DNA

Kinga Tóth,
Reinhold Wasserkort,
Ferenc Sipos,
Alexandra Kalmár,
Barnabás Wichmann,
Katalin Leiszter,
Gábor Valcz,
Márk Juhász,
Pál Miheller,
Árpád V. Patai

Published: December 19, 2014
https://doi.org/10.1371/journal.pone.0115415

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Colorectal cancer
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Adenomas
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Methylation
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DNA methylation
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Biopsy
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Septins
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Protein expression
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