Long-Term Pancreatic Beta Cell Exposure to High Levels of Glucose but Not Palmitate Induces DNA Methylation within the Insulin Gene Promoter and Represses Transcriptional Activity

• Kota Ishikawa,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Shin Tsunekawa ,

  * E-mail: tsune87@med.nagoya-u.ac.jp

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Makoto Ikeniwa,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Takako Izumoto,

  Affiliation Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Atsushi Iida,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Hidetada Ogata,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Eita Uenishi,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Yusuke Seino,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Nobuaki Ozaki,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Yoshihisa Sugimura,

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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• Yoji Hamada,

  Affiliation Department of Metabolic Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan

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• Akio Kuroda,

  Affiliation Diabetes Therapeutics and Research Center, The University of Tokushima, Tokushima, Japan

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• Keiko Shinjo,

  Affiliation Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

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• Yutaka Kondo,

  Affiliation Department of Epigenomics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan

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• Yutaka Oiso

  Affiliation Department of Endocrinology and Diabetes, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466–8550, Japan

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