Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

Kevin Blighe; Laura Kenny; Naina Patel; David S. Guttery; Karen Page; Julian H. Gronau; Cyrus Golshani; Justin Stebbing; R. Charles Coombes; Jacqueline A. Shaw

doi:10.1371/journal.pone.0115346

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Peer-reviewed

Research Article

Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

Kevin Blighe ,

¶These authors are joint first authors on this work.

Affiliation Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
⨯
Laura Kenny ,

¶These authors are joint first authors on this work.

Affiliation Division of Cancer, Imperial College, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
⨯
Naina Patel,

Affiliation Division of Cancer, Imperial College, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
⨯
David S. Guttery,

Affiliation Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
⨯
Karen Page,

Affiliation Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
⨯
Julian H. Gronau,

Affiliation Division of Cancer, Imperial College, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
⨯
Cyrus Golshani,

Affiliation Division of Cancer, Imperial College, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
⨯
Justin Stebbing,

Affiliation Division of Cancer, Imperial College, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
⨯
R. Charles Coombes,

Affiliation Division of Cancer, Imperial College, Hammersmith Hospital Campus, London, W12 0NN, United Kingdom
⨯
Jacqueline A. Shaw

* E-mail: js39@leicester.ac.uk

Affiliation Department of Cancer Studies and Molecular Medicine, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, LE2 7LX, United Kingdom
⨯

Whole Genome Sequence Analysis Suggests Intratumoral Heterogeneity in Dissemination of Breast Cancer to Lymph Nodes

Kevin Blighe,
Laura Kenny,
Naina Patel,
David S. Guttery,
Karen Page,
Julian H. Gronau,
Cyrus Golshani,
Justin Stebbing,
R. Charles Coombes,
Jacqueline A. Shaw

Published: December 29, 2014
https://doi.org/10.1371/journal.pone.0115346

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Breast cancer
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Metastasis
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Gastric cancer
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Cancer genomics
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Frameshift mutation
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Lymph nodes
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