NSK-01105, a Novel Sorafenib Derivative, Inhibits Human Prostate Tumor Growth via Suppression of VEGFR2/EGFR-Mediated Angiogenesis

Pengfei Yu; Liang Ye; Hongbo Wang; Guangying Du; Jianzhao Zhang; Yanhua Zuo; Jinghai Zhang; Jingwei Tian

doi:10.1371/journal.pone.0115041

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Open Access

Peer-reviewed

Research Article

NSK-01105, a Novel Sorafenib Derivative, Inhibits Human Prostate Tumor Growth via Suppression of VEGFR2/EGFR-Mediated Angiogenesis

Pengfei Yu,

Affiliation School of Life Science and Bio-pharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China
⨯
Liang Ye,

Affiliations State Key Laboratory of Long-acting and Targeting Drug Delivery System, Non-clinical Research Department, Luye Pharma Group Ltd., Yantai, Shandong 264003, China, School of Pharmaceutical Sciences and Institute of Material Medical, Binzhou Medical University, Yantai, Shandong 264005, China
⨯
Hongbo Wang,

Affiliations State Key Laboratory of Long-acting and Targeting Drug Delivery System, Non-clinical Research Department, Luye Pharma Group Ltd., Yantai, Shandong 264003, China, School of Pharmacy, Yantai University, Yantai, Shandong 264005, China
⨯
Guangying Du,

Affiliations State Key Laboratory of Long-acting and Targeting Drug Delivery System, Non-clinical Research Department, Luye Pharma Group Ltd., Yantai, Shandong 264003, China, School of Pharmacy, Yantai University, Yantai, Shandong 264005, China
⨯
Jianzhao Zhang,

Affiliation State Key Laboratory of Long-acting and Targeting Drug Delivery System, Non-clinical Research Department, Luye Pharma Group Ltd., Yantai, Shandong 264003, China
⨯
Yanhua Zuo,

Affiliation Affiliated Hospital of Medical College of Qingdao University, Qingdao, Shandong 266001, China
⨯
Jinghai Zhang ,

* E-mail: hazacar.2012@gmail.com (JZ); tianjingwei@luye.cn (JT)

Affiliation School of Life Science and Bio-pharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning 110016, China
⨯
Jingwei Tian

* E-mail: hazacar.2012@gmail.com (JZ); tianjingwei@luye.cn (JT)

Affiliations State Key Laboratory of Long-acting and Targeting Drug Delivery System, Non-clinical Research Department, Luye Pharma Group Ltd., Yantai, Shandong 264003, China, School of Pharmacy, Yantai University, Yantai, Shandong 264005, China
⨯

NSK-01105, a Novel Sorafenib Derivative, Inhibits Human Prostate Tumor Growth via Suppression of VEGFR2/EGFR-Mediated Angiogenesis

Pengfei Yu,
Liang Ye,
Hongbo Wang,
Guangying Du,
Jianzhao Zhang,
Yanhua Zuo,
Jinghai Zhang,
Jingwei Tian

Published: December 31, 2014
https://doi.org/10.1371/journal.pone.0115041

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