Altered Esophageal Histamine Receptor Expression in Eosinophilic Esophagitis (EoE): Implications on Disease Pathogenesis

Jamie Merves; Prasanna Modayur Chandramouleeswaran; Alain J. Benitez; Amanda B. Muir; Anna J. Lee; Diana M. Lim; Kara Dods; Isha Mehta; Eduardo D. Ruchelli; Hiroshi Nakagawa; Jonathan M. Spergel; Mei-Lun Wang

doi:10.1371/journal.pone.0114831

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Peer-reviewed

Research Article

Altered Esophageal Histamine Receptor Expression in Eosinophilic Esophagitis (EoE): Implications on Disease Pathogenesis

Jamie Merves ,

¶‡ These authors contributed equally to this work.

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Prasanna Modayur Chandramouleeswaran ,

¶‡ These authors contributed equally to this work.

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Alain J. Benitez,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Amanda B. Muir,

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Anna J. Lee,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Diana M. Lim,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Kara Dods,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
⨯
Isha Mehta,

Affiliation Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Eduardo D. Ruchelli,

Affiliation Division of Pathology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America
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Hiroshi Nakagawa,

Affiliation Department of Gastroenterology, Hepatology and Nutrition, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
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Jonathan M. Spergel,

Affiliations Division of Allergy and Immunology, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯
Mei-Lun Wang

* E-mail: wangm@email.chop.edu

Affiliations Division of Gastroenterology, Hepatology, and Nutrition, The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
⨯

Altered Esophageal Histamine Receptor Expression in Eosinophilic Esophagitis (EoE): Implications on Disease Pathogenesis

Jamie Merves,
Prasanna Modayur Chandramouleeswaran,
Alain J. Benitez,
Amanda B. Muir,
Anna J. Lee,
Diana M. Lim,
Kara Dods,
Isha Mehta,
Eduardo D. Ruchelli,
Hiroshi Nakagawa

Published: February 27, 2015
https://doi.org/10.1371/journal.pone.0114831

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Histamine
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Epithelial cells
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