Giant Lysosomes as a Chemotherapy Resistance Mechanism in Hepatocellular Carcinoma Cells

Federico Colombo; Elena Trombetta; Paola Cetrangolo; Marco Maggioni; Paola Razini; Francesca De Santis; Yvan Torrente; Daniele Prati; Erminio Torresani; Laura Porretti

doi:10.1371/journal.pone.0114787

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Peer-reviewed

Research Article

Giant Lysosomes as a Chemotherapy Resistance Mechanism in Hepatocellular Carcinoma Cells

Federico Colombo ,

* E-mail: federico.colombo@policlinico.mi.it

Affiliation Clinical Chemistry and Microbiology Laboratory, Flow Cytometry and Experimental Hepatology Service, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Elena Trombetta,

Affiliation Clinical Chemistry and Microbiology Laboratory, Flow Cytometry and Experimental Hepatology Service, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Paola Cetrangolo,

Affiliation Clinical Chemistry and Microbiology Laboratory, Flow Cytometry and Experimental Hepatology Service, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Marco Maggioni,

Affiliation Clinical Pathology Laboratory, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Paola Razini,

Affiliation Stem Cell Laboratory, University of Milan, Department of Pathophysiology and Transplantation, Centro Dino Ferrari, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Francesca De Santis,

Affiliation Stem Cell Laboratory, University of Milan, Department of Pathophysiology and Transplantation, Centro Dino Ferrari, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Yvan Torrente,

Affiliation Stem Cell Laboratory, University of Milan, Department of Pathophysiology and Transplantation, Centro Dino Ferrari, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Daniele Prati,

Affiliation Department of Transfusion Medicine and Hematology, Ospedale A. Manzoni, Lecco, Italy
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Erminio Torresani,

Affiliation Clinical Chemistry and Microbiology Laboratory, Flow Cytometry and Experimental Hepatology Service, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Laura Porretti

Affiliation Clinical Chemistry and Microbiology Laboratory, Flow Cytometry and Experimental Hepatology Service, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯

Giant Lysosomes as a Chemotherapy Resistance Mechanism in Hepatocellular Carcinoma Cells

Federico Colombo,
Elena Trombetta,
Paola Cetrangolo,
Marco Maggioni,
Paola Razini,
Francesca De Santis,
Yvan Torrente,
Daniele Prati,
Erminio Torresani,
Laura Porretti

Published: December 10, 2014
https://doi.org/10.1371/journal.pone.0114787

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