Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation

Emma E. Vincent; Douglas J. E. Elder; Linda O′Flaherty; Olivier E. Pardo; Piotr Dzien; Lois Phillips; Carys Morgan; Joya Pawade; Margaret T. May; Muhammad Sohail; Martin R. Hetzel; Michael J. Seckl; Jeremy M. Tavaré

doi:10.1371/journal.pone.0114725

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Open Access

Peer-reviewed

Research Article

Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation

Emma E. Vincent ,

Contributed equally to this work with: Emma E. Vincent, Douglas J. E. Elder

* E-mail: emma.vincent@mcgill.ca

Affiliations School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom, Department of Physiology, McIntyre Building, McGill University, Montreal, Quebec, H3G 1Y6, Canada
⨯
Douglas J. E. Elder ,

Contributed equally to this work with: Emma E. Vincent, Douglas J. E. Elder

Affiliation School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom
⨯
Linda O′Flaherty,

Affiliation School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom
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Olivier E. Pardo,

Affiliation Department of Oncology, Hammersmith Campus, Cyclotron Building, London, W12 0NN, United Kingdom
⨯
Piotr Dzien,

Affiliation School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom
⨯
Lois Phillips,

Affiliation Department of Respiratory Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom
⨯
Carys Morgan,

Affiliation School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom
⨯
Joya Pawade,

Affiliation Division of Histopathology, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, United Kingdom
⨯
Margaret T. May,

Affiliation School of Social and Community Medicine, Canynge Hall, University of Bristol, 39 Whatley Road, Bristol, BS8 2PS, United Kingdom
⨯
Muhammad Sohail,

Affiliation Division of Histopathology, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, United Kingdom
⨯
Martin R. Hetzel,

Affiliation Department of Respiratory Medicine, Bristol Royal Infirmary, Bristol, BS2 8HW, United Kingdom
⨯
Michael J. Seckl,

Affiliation Department of Oncology, Hammersmith Campus, Cyclotron Building, London, W12 0NN, United Kingdom
⨯
Jeremy M. Tavaré

Affiliation School of Biochemistry, Medical Sciences Building, University of Bristol, Bristol, BS8 1TD, United Kingdom
⨯

Glycogen Synthase Kinase 3 Protein Kinase Activity Is Frequently Elevated in Human Non-Small Cell Lung Carcinoma and Supports Tumour Cell Proliferation

Emma E. Vincent,
Douglas J. E. Elder,
Linda O′Flaherty,
Olivier E. Pardo,
Piotr Dzien,
Lois Phillips,
Carys Morgan,
Joya Pawade,
Margaret T. May,
Muhammad Sohail

Published: December 8, 2014
https://doi.org/10.1371/journal.pone.0114725

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