Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Ji-Feng Xu; Guang-hai Yang; Xiao-Hong Pan; Shui-Jun Zhang; Chen Zhao; Bin-Song Qiu; Hai-Feng Gu; Jian-Fei Hong; Li Cao; Yu Chen; Bing Xia; Qin Bi; Ya-Ping Wang

doi:10.1371/journal.pone.0114627

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Open Access

Peer-reviewed

Research Article

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Ji-Feng Xu ,

Contributed equally to this work with: Ji-Feng Xu, Guang-hai Yang, Xiao-Hong Pan

* E-mail: xu_jifeng@hotmail.com (JFX); wangypzju@163.com (YPW)

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Guang-hai Yang ,

Contributed equally to this work with: Ji-Feng Xu, Guang-hai Yang, Xiao-Hong Pan

Affiliation Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, PR China
⨯
Xiao-Hong Pan ,

Contributed equally to this work with: Ji-Feng Xu, Guang-hai Yang, Xiao-Hong Pan

Affiliation Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, PR China
⨯
Shui-Jun Zhang,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Chen Zhao,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Bin-Song Qiu,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Hai-Feng Gu,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Jian-Fei Hong,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Li Cao,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Yu Chen,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Bing Xia,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Qin Bi,

Affiliation Department of Orthopedics and Joint Surgery, Zhejiang Provincial People's Hospital, Hangzhou, 310014, PR China
⨯
Ya-Ping Wang

* E-mail: xu_jifeng@hotmail.com (JFX); wangypzju@163.com (YPW)

Affiliation Department of Cardiology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, PR China
⨯

Altered MicroRNA Expression Profile in Exosomes during Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells

Ji-Feng Xu,
Guang-hai Yang,
Xiao-Hong Pan,
Shui-Jun Zhang,
Chen Zhao,
Bin-Song Qiu,
Hai-Feng Gu,
Jian-Fei Hong,
Li Cao,
Yu Chen

Published: December 11, 2014
https://doi.org/10.1371/journal.pone.0114627

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MicroRNAs
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Exosomes
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Osteoblast differentiation
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Cell differentiation
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Wnt signaling cascade
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Mesenchymal stem cells
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Messenger RNA
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Gene expression
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