Dose-Dependent AMPK-Dependent and Independent Mechanisms of Berberine and Metformin Inhibition of mTORC1, ERK, DNA Synthesis and Proliferation in Pancreatic Cancer Cells

• Ming Ming,

  Affiliation Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• James Sinnett-Smith,

  Affiliations Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, CURE: Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Jia Wang,

  Affiliation Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Heloisa P. Soares,

  Affiliation Division of Hematology-Oncology, Department of Medicine David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Steven H. Young,

  Affiliations Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, CURE: Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Guido Eibl,

  Affiliations Department of Surgery, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, CURE: Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America

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• Enrique Rozengurt

  * E-mail: erozengurt@mednet.ucla.edu

  Affiliations Division of Digestive Diseases, Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, CURE: Digestive Diseases Research Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, Molecular Biology Institute, University of California Los Angeles, Los Angeles, California, United States of America

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