The Molecular Signature of the Stroma Response in Prostate Cancer-Induced Osteoblastic Bone Metastasis Highlights Expansion of Hematopoietic and Prostate Epithelial Stem Cell Niches

• Berna C. Özdemir ,

  Contributed equally to this work with: Berna C. Özdemir, Janine Hensel

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯
• Janine Hensel ,

  Contributed equally to this work with: Berna C. Özdemir, Janine Hensel

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯
• Chiara Secondini,

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯
• Antoinette Wetterwald,

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯
• Ruth Schwaninger,

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯
• Achim Fleischmann,

  Affiliation Institute of Pathology, University of Bern, Bern, Switzerland

  ⨯
• Wolfgang Raffelsberger,

  Affiliation Institut Génétique Biologie Moléculaire Cellulaire (IGBMC), Strasbourg, France

  ⨯
• Olivier Poch,

  Affiliation ICube UMR7357, University of Strasbourg, Strasbourg, France

  ⨯
• Mauro Delorenzi,

  Affiliation Ludwig Center for Cancer Research, Department of Oncology, University of Lausanne and Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  ⨯
• Ramzi Temanni,

  Affiliation Biomedical Informatics Division, Sidra Medical and Research Center, Doha, Qatar

  ⨯
• Ian G. Mills,

  Affiliation Prostate Cancer Research Group, Norway Centre for Molecular Medicine (NCMM), University of Oslo, Oslo, Norway

  ⨯
• Gabri van der Pluijm,

  Affiliation Department of Urology, Leiden University Medical Centre (LUMC), Leiden, The Netherlands

  ⨯
• George N. Thalmann,

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯
• Marco G. Cecchini

  * E-mail: marco.cecchini@dkf.unibe.ch

  Affiliation Urology Research Laboratory, Department of Urology and Department of Clinical Research, University of Bern, Bern, Switzerland

  ⨯