Accurate Measurement of Mitochondrial DNA Deletion Level and Copy Number Differences in Human Skeletal Muscle

John P. Grady; Julie L. Murphy; Emma L. Blakely; Ronald G. Haller; Robert W. Taylor; Doug M. Turnbull; Helen A. L. Tuppen

doi:10.1371/journal.pone.0114462

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Peer-reviewed

Research Article

Accurate Measurement of Mitochondrial DNA Deletion Level and Copy Number Differences in Human Skeletal Muscle

John P. Grady ,

Contributed equally to this work with: John P. Grady, Julie L. Murphy

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Julie L. Murphy ,

Contributed equally to this work with: John P. Grady, Julie L. Murphy

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Emma L. Blakely,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Ronald G. Haller,

Affiliation Department of Neurology, University of Texas Southwestern Medical Center and VA North Texas Medical Center, and Neuromuscular Center, Institute for Exercise and Environmental Medicine, Dallas, Texas, United States of America
⨯
Robert W. Taylor,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Doug M. Turnbull,

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Helen A. L. Tuppen

* E-mail: helen.tuppen@ncl.ac.uk

Current address: Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom

Affiliation Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

Accurate Measurement of Mitochondrial DNA Deletion Level and Copy Number Differences in Human Skeletal Muscle

John P. Grady,
Julie L. Murphy,
Emma L. Blakely,
Ronald G. Haller,
Robert W. Taylor,
Doug M. Turnbull,
Helen A. L. Tuppen

Published: December 4, 2014
https://doi.org/10.1371/journal.pone.0114462

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Mitochondrial DNA
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DNA replication
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Polymerase chain reaction
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Skeletal muscles
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Heteroplasmy
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Mitochondria
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Point mutation
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Genomics
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