A Putatively Functional Polymorphism in the HTR2C Gene is Associated with Depressive Symptoms in White Females Reporting Significant Life Stress

Beverly H. Brummett; Michael A. Babyak; Redford B. Williams; Kathleen Mullan Harris; Rong Jiang; William E. Kraus; Abanish Singh; Paul T. Costa; Anastasia Georgiades; Ilene C. Siegler

doi:10.1371/journal.pone.0114451

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Open Access

Peer-reviewed

Research Article

A Putatively Functional Polymorphism in the HTR2C Gene is Associated with Depressive Symptoms in White Females Reporting Significant Life Stress

Beverly H. Brummett ,

* E-mail: brummett@duke.edu

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Michael A. Babyak,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Redford B. Williams,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Kathleen Mullan Harris,

Affiliations Department of Sociology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Carolina Population Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
Rong Jiang,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
William E. Kraus,

Affiliation Duke Molecular Physiology Institute and Division of Cardiology, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Abanish Singh,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Paul T. Costa,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Anastasia Georgiades,

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯
Ilene C. Siegler

Affiliation Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, North Carolina, United States of America
⨯

A Putatively Functional Polymorphism in the HTR2C Gene is Associated with Depressive Symptoms in White Females Reporting Significant Life Stress

Beverly H. Brummett,
Michael A. Babyak,
Redford B. Williams,
Kathleen Mullan Harris,
Rong Jiang,
William E. Kraus,
Abanish Singh,
Paul T. Costa,
Anastasia Georgiades,
Ilene C. Siegler

Published: December 16, 2014
https://doi.org/10.1371/journal.pone.0114451

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Depression
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Psychological stress
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Cortisol
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Homozygosity
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Single nucleotide polymorphisms
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