Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice

Zachary B. Smithline; Anna S. Nikonova; Harvey H. Hensley; Kathy Q. Cai; Brian L. Egleston; David A. Proia; Tamina Seeger-Nukpezah; Erica A. Golemis

doi:10.1371/journal.pone.0114403

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Peer-reviewed

Research Article

Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice

Zachary B. Smithline ,

Contributed equally to this work with: Zachary B. Smithline, Anna S. Nikonova

Affiliations Yale University, New Haven, Connecticut, 06520, United States of America, Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯
Anna S. Nikonova ,

Contributed equally to this work with: Zachary B. Smithline, Anna S. Nikonova

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯
Harvey H. Hensley,

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯
Kathy Q. Cai,

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯
Brian L. Egleston,

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯
David A. Proia,

Affiliation Synta Pharmaceuticals, Lexington, Massachusetts, 02421, United States of America
⨯
Tamina Seeger-Nukpezah ,

* E-mail: Erica.Golemis@fccc.edu (EAG); tamina.seeger-nukpezah@uk-koeln.de (TSN)

Affiliations Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America, Department I of Internal Medicine, Center for Integrated Oncology, University Hospital of Cologne, Cologne, 50937, Germany
⨯
Erica A. Golemis

* E-mail: Erica.Golemis@fccc.edu (EAG); tamina.seeger-nukpezah@uk-koeln.de (TSN)

Affiliation Program in Molecular Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania, 19111, United States of America
⨯

Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice

Zachary B. Smithline,
Anna S. Nikonova,
Harvey H. Hensley,
Kathy Q. Cai,
Brian L. Egleston,
David A. Proia,
Tamina Seeger-Nukpezah,
Erica A. Golemis

Published: December 4, 2014
https://doi.org/10.1371/journal.pone.0114403

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Heat shock response
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Magnetic resonance imaging
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Liver and spleen scan
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