Phosphorylation of Ribosomal Protein S6 Kinase 1 at Thr421/Ser424 and Dephosphorylation at Thr389 Regulates SP600125-Induced Polyploidization of Megakaryocytic Cell Lines

Chang-Ling Li; Jin-Gang Yang; Di Lin; Yong-Shan Zhao; Shuo Liu; Si-Ning Xing; Song Zhao; Cong-Qin Chen; Zhi-Ming Jiang; Fei-Fei Pu; Jian-Ping Cao; Dong-Chu Ma

doi:10.1371/journal.pone.0114389

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Open Access

Peer-reviewed

Research Article

Phosphorylation of Ribosomal Protein S6 Kinase 1 at Thr421/Ser424 and Dephosphorylation at Thr389 Regulates SP600125-Induced Polyploidization of Megakaryocytic Cell Lines

Chang-Ling Li ,

Contributed equally to this work with: Chang-Ling Li, Jin-Gang Yang

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Jin-Gang Yang ,

Contributed equally to this work with: Chang-Ling Li, Jin-Gang Yang

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Di Lin,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Yong-Shan Zhao,

Affiliation School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning, China
⨯
Shuo Liu,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Si-Ning Xing,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Song Zhao,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Cong-Qin Chen,

Affiliation Clinical Pharmacy, Shenyang Pharmaceutical University, Shenhe District, Shenyang, Liaoning, China
⨯
Zhi-Ming Jiang,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Fei-Fei Pu,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Jian-Ping Cao,

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯
Dong-Chu Ma

* E-mail: mdc580819@sina.com

Affiliation Department of Experimental Medicine, General Hospital of Shenyang Military Area Command, Shenhe District, Shenyang, Liaoning, China
⨯

Phosphorylation of Ribosomal Protein S6 Kinase 1 at Thr421/Ser424 and Dephosphorylation at Thr389 Regulates SP600125-Induced Polyploidization of Megakaryocytic Cell Lines

Chang-Ling Li,
Jin-Gang Yang,
Di Lin,
Yong-Shan Zhao,
Shuo Liu,
Si-Ning Xing,
Song Zhao,
Cong-Qin Chen,
Zhi-Ming Jiang,
Fei-Fei Pu

Published: December 8, 2014
https://doi.org/10.1371/journal.pone.0114389

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