Central Nervous System Effects of the Second-Generation Antihistamines Marketed in Japan -Review of Inter-Drug Differences Using the Proportional Impairment Ratio (PIR)-

• Tatsuya Isomura ,

  * E-mail: tatsuya_isomura@jp-css.com

  Affiliations CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan, Institute of Medical Science, Tokyo Medical University, Tokyo, Japan

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• Takeshi Kono,

  Affiliation Department of Dermatology, Nippon Medical School Chiba-Hokusoh Hospital, Chiba, Japan

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• Ian Hindmarch,

  Affiliation University of Surrey, Guildford, Surrey, United Kingdom

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• Norimasa Kikuchi,

  Affiliation CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan

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• Aya Murakami,

  Affiliation CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan

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• Kyoko Inuzuka,

  Affiliation CLINICAL STUDY SUPPORT, Inc., Nagoya, Aichi, Japan

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• Seiji Kawana

  Affiliation Department of Dermatology, Nippon Medical School, Tokyo, Japan

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