ADH1B and ADH1C Genotype, Alcohol Consumption and Biomarkers of Liver Function: Findings from a Mendelian Randomization Study in 58,313 European Origin Danes

Debbie A. Lawlor; Marianne Benn; Luisa Zuccolo; N. Maneka G. De Silva; Anne Tybjaerg-Hansen; George Davey Smith; Børge G. Nordestgaard

doi:10.1371/journal.pone.0114294

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Peer-reviewed

Research Article

ADH1B and ADH1C Genotype, Alcohol Consumption and Biomarkers of Liver Function: Findings from a Mendelian Randomization Study in 58,313 European Origin Danes

Debbie A. Lawlor ,

* E-mail: d.a.lawlor@bristol.ac.uk

Affiliations MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Marianne Benn,

Affiliations The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark
⨯
Luisa Zuccolo,

Affiliations MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
N. Maneka G. De Silva,

Affiliation MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom
⨯
Anne Tybjaerg-Hansen,

Affiliations The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, Denmark
⨯
George Davey Smith,

Affiliations MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom, School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom
⨯
Børge G. Nordestgaard

Affiliations The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark, Copenhagen University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark, Department of Clinical Biochemistry, Herlev Hospital, Copenhagen, Denmark
⨯

ADH1B and ADH1C Genotype, Alcohol Consumption and Biomarkers of Liver Function: Findings from a Mendelian Randomization Study in 58,313 European Origin Danes

Debbie A. Lawlor,
Marianne Benn,
Luisa Zuccolo,
N. Maneka G. De Silva,
Anne Tybjaerg-Hansen,
George Davey Smith,
Børge G. Nordestgaard

Published: December 15, 2014
https://doi.org/10.1371/journal.pone.0114294

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Genetics
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Serine proteases
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