The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile

Venkatesh P. Kashi; Rajesh A. Jacob; Raghavendra A. Shamanna; Malini Menon; Anangi Balasiddaiah; Rebu K. Varghese; Mahesh Bachu; Udaykumar Ranga

doi:10.1371/journal.pone.0114155

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Open Access

Peer-reviewed

Research Article

The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile

Venkatesh P. Kashi,

Affiliation HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India
⨯
Rajesh A. Jacob,

Affiliations HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India, Cellular Immunology Group, International Center for Genetic Engineering and Biotechnology, Cape Town, South Africa
⨯
Raghavendra A. Shamanna,

Affiliations HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India, Laboratory of Molecular Gerontology, National Institute on Aging, Baltimore, Maryland, United States of America
⨯
Malini Menon,

Affiliation HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India
⨯
Anangi Balasiddaiah,

Affiliation HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India
⨯
Rebu K. Varghese,

Affiliation HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India
⨯
Mahesh Bachu,

Affiliation HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India
⨯
Udaykumar Ranga

* E-mail: udaykumar@jncasr.ac.in

Affiliation HIV/AIDS laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, 560064, India
⨯

The Grafting of Universal T-Helper Epitopes Enhances Immunogenicity of HIV-1 Tat Concurrently Improving Its Safety Profile

Venkatesh P. Kashi,
Rajesh A. Jacob,
Raghavendra A. Shamanna,
Malini Menon,
Anangi Balasiddaiah,
Rebu K. Varghese,
Mahesh Bachu,
Udaykumar Ranga

Published: December 22, 2014
https://doi.org/10.1371/journal.pone.0114155

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