The Effects of Two Polymorphisms on p21cip1 Function and Their Association with Alzheimer’s Disease in a Population of European Descent

Sharon C. Yates; Amen Zafar; Erzsebet M. Rabai; James B. Foxall; Sheila Nagy; Karen E. Morrison; Carl Clarke; Margaret M. Esiri; Sharon Christie; A. David Smith; Zsuzsanna Nagy

doi:10.1371/journal.pone.0114050

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Open Access

Peer-reviewed

Research Article

The Effects of Two Polymorphisms on p21^cip1 Function and Their Association with Alzheimer’s Disease in a Population of European Descent

Sharon C. Yates,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
Amen Zafar,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
Erzsebet M. Rabai,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
James B. Foxall,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
Sheila Nagy,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
Karen E. Morrison,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
Carl Clarke,

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯
Margaret M. Esiri,

Affiliation Department of Neuropathology, University of Oxford, Level 1, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
⨯
Sharon Christie,

Affiliation OPTIMA, University of Oxford, Level 4, John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
⨯
A. David Smith,

Affiliation Department of Pharmacology, University of Oxford, Mansfield Road, Oxford, OX1 3QT, United Kingdom
⨯
Zsuzsanna Nagy

* E-mail: z.nagy@bham.ac.uk

Affiliation Neuropharmacology and Neurobiology, College of Medical and Dental Sciences, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT, United Kingdom
⨯

The Effects of Two Polymorphisms on p21^cip1 Function and Their Association with Alzheimer’s Disease in a Population of European Descent

Sharon C. Yates,
Amen Zafar,
Erzsebet M. Rabai,
James B. Foxall,
Sheila Nagy,
Karen E. Morrison,
Carl Clarke,
Margaret M. Esiri,
Sharon Christie,
A. David Smith

Published: January 27, 2015
https://doi.org/10.1371/journal.pone.0114050

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Transfection
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Parkinson disease
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Protein expression
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Single nucleotide polymorphisms
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