Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2

Peifeng Hou; Ching-Ying Kuo; Chun-Ting Cheng; Jing-Ping Liou; David K. Ann; Qiang Chen

doi:10.1371/journal.pone.0113865

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Research Article

Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2

Peifeng Hou,

Affiliations Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America, Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China, Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China
⨯
Ching-Ying Kuo,

Affiliations Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America, Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America
⨯
Chun-Ting Cheng,

Affiliations Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America, Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America
⨯
Jing-Ping Liou,

Affiliation School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei, Taiwan
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David K. Ann ,

* E-mail: dann@coh.org (DKA); cqiang8@189.cn (QC)

Affiliations Department of Molecular Pharmacology, Beckman Research Institute, City of Hope, Duarte, California, United States of America, Irell & Manella Graduate School of Biological Sciences, Beckman Research Institute, City of Hope, Duarte, California, United States of America
⨯
Qiang Chen

* E-mail: dann@coh.org (DKA); cqiang8@189.cn (QC)

Affiliations Department of Oncology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China, Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China
⨯

Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2

Peifeng Hou,
Ching-Ying Kuo,
Chun-Ting Cheng,
Jing-Ping Liou,
David K. Ann,
Qiang Chen

Published: November 24, 2014
https://doi.org/10.1371/journal.pone.0113865

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