A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement

Bai Xue; Cheng Zhang; Yihan Wang; Jincheng Wang; Jien Zhang; Min Lu; Guodong Li; Zhizhong Cao; Qingshan Huang

doi:10.1371/journal.pone.0113797

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Open Access

Peer-reviewed

Research Article

A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement

Bai Xue ,

Contributed equally to this work with: Bai Xue, Cheng Zhang

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, 200433, PR China
⨯
Cheng Zhang ,

Contributed equally to this work with: Bai Xue, Cheng Zhang

Affiliations State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, 200433, PR China, Shanghai High-Tech United Bio-Technological R&D Co., Ltd, 501 Jingang Road, Shanghai, 201206, PR China
⨯
Yihan Wang,

Affiliation Shanghai High-Tech United Bio-Technological R&D Co., Ltd, 501 Jingang Road, Shanghai, 201206, PR China
⨯
Jincheng Wang,

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, 200433, PR China
⨯
Jien Zhang,

Affiliation Shanghai High-Tech United Bio-Technological R&D Co., Ltd, 501 Jingang Road, Shanghai, 201206, PR China
⨯
Min Lu,

Affiliation Shanghai High-Tech United Bio-Technological R&D Co., Ltd, 501 Jingang Road, Shanghai, 201206, PR China
⨯
Guodong Li,

Affiliation Shanghai High-Tech United Bio-Technological R&D Co., Ltd, 501 Jingang Road, Shanghai, 201206, PR China
⨯
Zhizhong Cao ,

* E-mail: qshuang@fudan.edu.cn (QH); caozhizh@263.net (ZC)

Affiliation Department of Stomatology, Changhai Hospital, Second Military Medical University, 168 Changhai Road, Shanghai, 200433, PR China
⨯
Qingshan Huang

* E-mail: qshuang@fudan.edu.cn (QH); caozhizh@263.net (ZC)

Affiliations State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, 200433, PR China, Shanghai High-Tech United Bio-Technological R&D Co., Ltd, 501 Jingang Road, Shanghai, 201206, PR China
⨯

A Novel Controlled-Release System for Antibacterial Enzyme Lysostaphin Delivery Using Hydroxyapatite/Chitosan Composite Bone Cement

Bai Xue,
Cheng Zhang,
Yihan Wang,
Jincheng Wang,
Jien Zhang,
Min Lu,
Guodong Li,
Zhizhong Cao,
Qingshan Huang

Published: December 2, 2014
https://doi.org/10.1371/journal.pone.0113797

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