Tumor Necrosis Factor-α Sensitizes Breast Cancer Cells to Natural Products with Proteasome-Inhibitory Activity Leading to Apoptosis

Li Lu; Wenli Shi; Rahul R. Deshmukh; Jie Long; Xiaoli Cheng; Weidong Ji; Guohua Zeng; Xianliang Chen; Yajie Zhang; Q. Ping Dou

doi:10.1371/journal.pone.0113783

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Open Access

Peer-reviewed

Research Article

Tumor Necrosis Factor-α Sensitizes Breast Cancer Cells to Natural Products with Proteasome-Inhibitory Activity Leading to Apoptosis

Li Lu ,

¶These authors are co-first authors on this work.

Affiliations Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong Province, China, Department of Pathology and Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, United States of America
⨯
Wenli Shi ,

¶These authors are co-first authors on this work.

Affiliation Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong Province, China
⨯
Rahul R. Deshmukh,

Affiliation Department of Pathology and Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, United States of America
⨯
Jie Long,

Affiliation Department of Pathology, Guangzhou Medical University, Guangzhou, Guangdong Province, China
⨯
Xiaoli Cheng,

Affiliation Department of Pathophysiology, Guangzhou Medical University, Guangzhou, Guangdong Province, China
⨯
Weidong Ji,

Affiliation Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, Guangdong Province, China
⨯
Guohua Zeng,

Affiliation Department of Urology, Minimally Invasive Surgery Center, The First Affiliated Hospital of Guangzhou Medical University, Guangdong Provincial Key Laboratory of Urology, Guangzhou, Guangdong Province, China
⨯
Xianliang Chen,

Affiliation Department of Pathology, Guangzhou Medical University, Guangzhou, Guangdong Province, China
⨯
Yajie Zhang ,

* E-mail: yajie.zhang@163.com (YZ); doup@karmanos.org (QPD)

Affiliation Department of Pathology, Guangzhou Medical University, Guangzhou, Guangdong Province, China
⨯
Q. Ping Dou

* E-mail: yajie.zhang@163.com (YZ); doup@karmanos.org (QPD)

Affiliations Department of Pathology and Karmanos Cancer Institute, School of Medicine, Wayne State University, Detroit, Michigan, United States of America, Departments of Oncology and Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan, United States of America
⨯

Tumor Necrosis Factor-α Sensitizes Breast Cancer Cells to Natural Products with Proteasome-Inhibitory Activity Leading to Apoptosis

Li Lu,
Wenli Shi,
Rahul R. Deshmukh,
Jie Long,
Xiaoli Cheng,
Weidong Ji,
Guohua Zeng,
Xianliang Chen,
Yajie Zhang,
Q. Ping Dou

Published: November 24, 2014
https://doi.org/10.1371/journal.pone.0113783

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