Specificity Rendering ‘Hot-Spots’ for Aurora Kinase Inhibitor Design: The Role of Non-Covalent Interactions and Conformational Transitions

Open Access

Peer-reviewed

Research Article

Preethi Badrinarayan,

Affiliation Molecular Modeling Group, Organic Chemical Sciences, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad- 500 607, India
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G. Narahari Sastry

* E-mail: gnsastry@gmail.com

Affiliation Molecular Modeling Group, Organic Chemical Sciences, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad- 500 607, India
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Drug interactions
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Crystal structure
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Salt bridges
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Biochemical simulations
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Sequence alignment
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Adenine
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Sequence motif analysis
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Protein kinases
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