Regulation of PKM2 and Nrf2-ARE Pathway during Benzoquinone Induced Oxidative Stress in Yolk Sac Hematopoietic Stem Cells

Jie Zhu; Zhuoyue Bi; Tan Yang; Wei Wang; Zhen Li; Wenting Huang; Liping Wang; Shaozun Zhang; Yanfeng Zhou; Ningna Fan; YuE Bai; Wentao Song; Chunhong Wang; Hong Wang; Yongyi Bi

doi:10.1371/journal.pone.0113733

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Open Access

Peer-reviewed

Research Article

Regulation of PKM2 and Nrf2-ARE Pathway during Benzoquinone Induced Oxidative Stress in Yolk Sac Hematopoietic Stem Cells

Jie Zhu ,

Contributed equally to this work with: Jie Zhu, Zhuoyue Bi

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Zhuoyue Bi ,

Contributed equally to this work with: Jie Zhu, Zhuoyue Bi

Affiliation Hubei Provincial Key Laboratory for Applied Toxicology (Hubei Provincial Academy for Preventive Medicine), Wuhan, P.R. China
⨯
Tan Yang,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Wei Wang,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Zhen Li,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Wenting Huang,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Liping Wang,

Affiliation School of Public Health, Kunming Medical University, Chenggong District, Kunming, P.R. China
⨯
Shaozun Zhang,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Yanfeng Zhou,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Ningna Fan,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
YuE Bai,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Wentao Song,

Affiliation Nanchang Center for Disease Control and Prevention, Nanchang, P.R. China
⨯
Chunhong Wang,

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Hong Wang ,

* E-mail: whwhgyg@163.com (HW); yongyib@aliyun.com (YYB)

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯
Yongyi Bi

* E-mail: whwhgyg@163.com (HW); yongyib@aliyun.com (YYB)

Affiliations School of Public Health, Wuhan University, Wuhan, Hubei, P.R. China, Hubei Key Laboratory of Allergy and Immune-related Diseases, Wuhan, Hubei, P.R. China, Hubei Biomass-resource Chemistry and Environmental Biotechnology Key Laboratory, Wuhan University, Wuhan, Hubei, P.R. China
⨯

Regulation of PKM2 and Nrf2-ARE Pathway during Benzoquinone Induced Oxidative Stress in Yolk Sac Hematopoietic Stem Cells

Jie Zhu,
Zhuoyue Bi,
Tan Yang,
Wei Wang,
Zhen Li,
Wenting Huang,
Liping Wang,
Shaozun Zhang,
Yanfeng Zhou,
Ningna Fan

Published: December 1, 2014
https://doi.org/10.1371/journal.pone.0113733

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