Induced Differentiation of Human Myeloid Leukemia Cells into M2 Macrophages by Combined Treatment with Retinoic Acid and 1α,25-Dihydroxyvitamin D3

Hiromichi Takahashi; Yoshihiro Hatta; Noriyoshi Iriyama; Yuichiro Hasegawa; Hikaru Uchida; Masaru Nakagawa; Makoto Makishima; Jin Takeuchi; Masami Takei

doi:10.1371/journal.pone.0113722

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Peer-reviewed

Research Article

Induced Differentiation of Human Myeloid Leukemia Cells into M2 Macrophages by Combined Treatment with Retinoic Acid and 1α,25-Dihydroxyvitamin D₃

Hiromichi Takahashi,

Affiliations Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan, Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Yoshihiro Hatta,

Affiliation Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Noriyoshi Iriyama,

Affiliation Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Yuichiro Hasegawa,

Affiliation Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan
⨯
Hikaru Uchida,

Affiliation Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan
⨯
Masaru Nakagawa,

Affiliations Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan, Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Makoto Makishima ,

* E-mail: makishima.makoto@nihon-u.ac.jp

Affiliation Division of Biochemistry, Department of Biomedical Sciences, Nihon University School of Medicine, Tokyo, Japan
⨯
Jin Takeuchi,

Current address: Department of Internal Medicine, International University of Health and Welfare Shioya Hospital, Yaita, Tochigi, Japan

Affiliation Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯
Masami Takei

Affiliation Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan
⨯

Induced Differentiation of Human Myeloid Leukemia Cells into M2 Macrophages by Combined Treatment with Retinoic Acid and 1α,25-Dihydroxyvitamin D₃

Hiromichi Takahashi,
Yoshihiro Hatta,
Noriyoshi Iriyama,
Yuichiro Hasegawa,
Hikaru Uchida,
Masaru Nakagawa,
Makoto Makishima,
Jin Takeuchi,
Masami Takei

Published: November 19, 2014
https://doi.org/10.1371/journal.pone.0113722

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Cell differentiation
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HL60 cells
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Macrophages
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Myeloid leukemia
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Cancer treatment
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Gene expression
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Leukemia cells
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Retinoid signaling
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