C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/smad3 and IKBα Pathway

Ling Li; Qinghua Yin; Xi Tang; Lin Bai; Jie Zhang; Shenju Gou; Hongping Zhu; Jingqiu Cheng; Ping Fu; Fang Liu

doi:10.1371/journal.pone.0113639

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Open Access

Peer-reviewed

Research Article

C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/smad3 and IKBα Pathway

Ling Li,

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Qinghua Yin,

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Xi Tang,

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Lin Bai,

Affiliation Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, Regenerative Medicine Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Jie Zhang,

Affiliation Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, Regenerative Medicine Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Shenju Gou,

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Hongping Zhu,

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Jingqiu Cheng,

Affiliation Key Laboratory of Transplant Engineering and Immunology, Ministry of Health, Regenerative Medicine Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Ping Fu ,

* E-mail: fupinghx@163.com (PF); liufangfh@163.com (FL)

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯
Fang Liu

* E-mail: fupinghx@163.com (PF); liufangfh@163.com (FL)

Affiliation Division of Nephrology, West China Hospital of Sichuan University, Chengdu, Sichuan, China
⨯

C3a Receptor Antagonist Ameliorates Inflammatory and Fibrotic Signals in Type 2 Diabetic Nephropathy by Suppressing the Activation of TGF-β/smad3 and IKBα Pathway

Ling Li,
Qinghua Yin,
Xi Tang,
Lin Bai,
Jie Zhang,
Shenju Gou,
Hongping Zhu,
Jingqiu Cheng,
Ping Fu,
Fang Liu

Published: November 25, 2014
https://doi.org/10.1371/journal.pone.0113639

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