Role of Ca²⁺ and L-Phe in Regulating Functional Cooperativity of Disease-Associated “Toggle” Calcium-Sensing Receptor Mutations

• Chen Zhang,

  Affiliations Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, United States of America

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• Nagaraju Mulpuri,

  Affiliation Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America

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• Fadil M. Hannan,

  Affiliation Academic Endocrine Unit, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom

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• M. Andrew Nesbit,

  Affiliation Academic Endocrine Unit, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom

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• Rajesh V. Thakker,

  Affiliation Academic Endocrine Unit, University of Oxford, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford, United Kingdom

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• Donald Hamelberg,

  Affiliations Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, United States of America

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• Edward M. Brown,

  Affiliation Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, United States of America

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• Jenny J. Yang

  * E-mail: chejjy@langate.gsu.edu

  Affiliations Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia, United States of America

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