Anti-CD45 Radioimmunotherapy with 90Y but Not 177Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

Johnnie J. Orozco; Ethan R. Balkin; Ted A. Gooley; Aimee Kenoyer; Donald K. Hamlin; D. Scott Wilbur; Darrell R. Fisher; Mark D. Hylarides; Mazyar Shadman; Damian J. Green; Ajay K. Gopal; Oliver W. Press; John M. Pagel

doi:10.1371/journal.pone.0113601

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Open Access

Peer-reviewed

Research Article

Anti-CD45 Radioimmunotherapy with ⁹⁰Y but Not ¹⁷⁷Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

Johnnie J. Orozco ,

¶These authors are co-first authors on this work.

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Hematology Division, University of Washington, Seattle, WA, United States of America
⨯
Ethan R. Balkin ,

¶These authors are co-first authors on this work.

Affiliation Radiation Oncology, University of Washington, Seattle, WA, United States of America
⨯
Ted A. Gooley,

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
⨯
Aimee Kenoyer,

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
⨯
Donald K. Hamlin,

Affiliation Radiation Oncology, University of Washington, Seattle, WA, United States of America
⨯
D. Scott Wilbur,

Affiliation Radiation Oncology, University of Washington, Seattle, WA, United States of America
⨯
Darrell R. Fisher,

Affiliation Dade Moeller Health Group, Richland, WA, United States of America
⨯
Mark D. Hylarides,

Affiliation Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America
⨯
Mazyar Shadman,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Hematology Division, University of Washington, Seattle, WA, United States of America
⨯
Damian J. Green,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Medical Oncology, University of Washington, Seattle, WA, United States of America
⨯
Ajay K. Gopal,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Medical Oncology, University of Washington, Seattle, WA, United States of America
⨯
Oliver W. Press,

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Medical Oncology, University of Washington, Seattle, WA, United States of America
⨯
John M. Pagel

* E-mail: jpagel@fhcrc.org

Affiliations Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States of America, Medical Oncology, University of Washington, Seattle, WA, United States of America
⨯

Anti-CD45 Radioimmunotherapy with ⁹⁰Y but Not ¹⁷⁷Lu Is Effective Treatment in a Syngeneic Murine Leukemia Model

Johnnie J. Orozco,
Ethan R. Balkin,
Ted A. Gooley,
Aimee Kenoyer,
Donald K. Hamlin,
D. Scott Wilbur,
Darrell R. Fisher,
Mark D. Hylarides,
Mazyar Shadman,
Damian J. Green

Published: December 2, 2014
https://doi.org/10.1371/journal.pone.0113601

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