Structure-Based Network Analysis of Activation Mechanisms in the ErbB Family of Receptor Tyrosine Kinases: The Regulatory Spine Residues Are Global Mediators of Structural Stability and Allosteric Interactions

Open Access

Peer-reviewed

Research Article

Kevin A. James,

Affiliation School of Computational Sciences and Crean School of Health and Life Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America
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Gennady M. Verkhivker

* E-mail: verkhivk@chapman.edu

Affiliations School of Computational Sciences and Crean School of Health and Life Sciences, Schmid College of Science and Technology, Chapman University, Orange, California, United States of America, Department of Pharmacology, University of California San Diego, La Jolla, California, United States of America
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Crystal structure
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Centrality
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Dimers
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Interaction networks
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Monomers
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Communications
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Protein structure networks
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Allosteric regulation
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