Amyotrophic Lateral Sclerosis-Linked Mutant VAPB Inclusions Do Not Interfere with Protein Degradation Pathways or Intracellular Transport in a Cultured Cell Model

Paola Genevini; Giulia Papiani; Annamaria Ruggiano; Lavinia Cantoni; Francesca Navone; Nica Borgese

doi:10.1371/journal.pone.0113416

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Peer-reviewed

Research Article

Amyotrophic Lateral Sclerosis-Linked Mutant VAPB Inclusions Do Not Interfere with Protein Degradation Pathways or Intracellular Transport in a Cultured Cell Model

Paola Genevini,

Affiliation Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milano, Italy
⨯
Giulia Papiani,

Current address: Oligomerix, Inc., New York, New York, United States of America

Affiliation Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milano, Italy
⨯
Annamaria Ruggiano,

Current address: Cell and Developmental Biology Programme, Centre for Genomic Regulation (CRG), Barcelona, Spain

Affiliation Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milano, Italy
⨯
Lavinia Cantoni,

Affiliation Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche “Mario Negri”, Milan, Italy
⨯
Francesca Navone ,

* E-mail: f.navone@in.cnr.it (FN); n.borgese@in.cnr.it (NB)

Affiliation Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milano, Italy
⨯
Nica Borgese

* E-mail: f.navone@in.cnr.it (FN); n.borgese@in.cnr.it (NB)

Affiliations Institute of Neuroscience, Consiglio Nazionale delle Ricerche, and Department of Medical Biotechnology and Translational Medicine (BIOMETRA), Università degli Studi di Milano, Milano, Italy, Department of Health Science, Magna Graecia University of Catanzaro, Catanzaro, Italy
⨯

Amyotrophic Lateral Sclerosis-Linked Mutant VAPB Inclusions Do Not Interfere with Protein Degradation Pathways or Intracellular Transport in a Cultured Cell Model

Paola Genevini,
Giulia Papiani,
Annamaria Ruggiano,
Lavinia Cantoni,
Francesca Navone,
Nica Borgese

Published: November 19, 2014
https://doi.org/10.1371/journal.pone.0113416

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