STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis

Stefan Chmielewski; Adam Olejnik; Krzysztof Sikorski; Jaroslav Pelisek; Katarzyna Błaszczyk; Cristiane Aoqui; Hanna Nowicka; Alma Zernecke; Uwe Heemann; Joanna Wesoly; Marcus Baumann; Hans A. R. Bluyssen

doi:10.1371/journal.pone.0113318

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Open Access

Peer-reviewed

Research Article

STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis

Stefan Chmielewski,

Affiliations Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany, Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯
Adam Olejnik,

Affiliation Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯
Krzysztof Sikorski,

Affiliation Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯
Jaroslav Pelisek,

Affiliation Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
⨯
Katarzyna Błaszczyk,

Affiliation Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯
Cristiane Aoqui,

Affiliation Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
⨯
Hanna Nowicka,

Affiliation Laboratory of High-throughput Technologies, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯
Alma Zernecke,

Affiliations Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University Munich, Munich, Germany, German Centre for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany
⨯
Uwe Heemann,

Affiliation Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
⨯
Joanna Wesoly,

Affiliation Laboratory of High-throughput Technologies, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯
Marcus Baumann,

Affiliation Department of Nephrology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany
⨯
Hans A. R. Bluyssen

* E-mail: h.bluyss@amu.edu.pl

Affiliation Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University Poznan, Poznan, Poland
⨯

STAT1-Dependent Signal Integration between IFNγ and TLR4 in Vascular Cells Reflect Pro-Atherogenic Responses in Human Atherosclerosis

Stefan Chmielewski,
Adam Olejnik,
Krzysztof Sikorski,
Jaroslav Pelisek,
Katarzyna Błaszczyk,
Cristiane Aoqui,
Hanna Nowicka,
Alma Zernecke,
Uwe Heemann,
Joanna Wesoly

Published: December 5, 2014
https://doi.org/10.1371/journal.pone.0113318

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Signal amplification
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Immune response
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Gene regulation
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STAT signaling
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