The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

Philip D. Townsend; Britta Jungwirth; Florence Pojer; Michael Bußmann; Victoria A. Money; Stewart T. Cole; Alfred Pühler; Andreas Tauch; Michael Bott; Martin J. Cann; Ehmke Pohl

doi:10.1371/journal.pone.0113265

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Peer-reviewed

Research Article

The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

Philip D. Townsend,

Affiliation School of Biological and Biomedical Sciences & Department of Chemistry, Biophysical Sciences Institute, Durham University, Durham, United Kingdom
⨯
Britta Jungwirth,

Affiliation Institute for Genome Research and Systems Biology, Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany
⨯
Florence Pojer,

Affiliation Global Health Institute, Protein Crystallography Core Facility, Ecole Poytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
⨯
Michael Bußmann,

Affiliation Institute of Bio- and Geosciences, IBG-1:Biotechnology, Forschungszentrum Jülich, Jülich, Germany
⨯
Victoria A. Money,

Affiliation School of Biological and Biomedical Sciences & Department of Chemistry, Biophysical Sciences Institute, Durham University, Durham, United Kingdom
⨯
Stewart T. Cole,

Affiliation Global Health Institute, Protein Crystallography Core Facility, Ecole Poytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland
⨯
Alfred Pühler,

Affiliation Institute for Genome Research and Systems Biology, Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany
⨯
Andreas Tauch,

Affiliation Institute for Genome Research and Systems Biology, Center for Biotechnology (CeBiTec), Bielefeld University, Bielefeld, Germany
⨯
Michael Bott,

Affiliation Institute of Bio- and Geosciences, IBG-1:Biotechnology, Forschungszentrum Jülich, Jülich, Germany
⨯
Martin J. Cann,

Affiliation School of Biological and Biomedical Sciences & Department of Chemistry, Biophysical Sciences Institute, Durham University, Durham, United Kingdom
⨯
Ehmke Pohl

* E-mail: ehmke.pohl@durham.ac.uk

Affiliation School of Biological and Biomedical Sciences & Department of Chemistry, Biophysical Sciences Institute, Durham University, Durham, United Kingdom
⨯

The Crystal Structures of Apo and cAMP-Bound GlxR from Corynebacterium glutamicum Reveal Structural and Dynamic Changes upon cAMP Binding in CRP/FNR Family Transcription Factors

Philip D. Townsend,
Britta Jungwirth,
Florence Pojer,
Michael Bußmann,
Victoria A. Money,
Stewart T. Cole,
Alfred Pühler,
Andreas Tauch,
Michael Bott,
Martin J. Cann

Published: December 3, 2014
https://doi.org/10.1371/journal.pone.0113265

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