Peroxisome Proliferator-Activated Receptor γ Deficiency in T Cells Accelerates Chronic Rejection by Influencing the Differentiation of CD4+ T Cells and Alternatively Activated Macrophages

Xiaofan Huang; Lingyun Ren; Ping Ye; Chao Cheng; Jie Wu; Sihua Wang; Yuan Sun; Zheng Liu; Aini Xie; Jiahong Xia

doi:10.1371/journal.pone.0112953

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Peer-reviewed

Research Article

Peroxisome Proliferator-Activated Receptor γ Deficiency in T Cells Accelerates Chronic Rejection by Influencing the Differentiation of CD4+ T Cells and Alternatively Activated Macrophages

Xiaofan Huang ,

Contributed equally to this work with: Xiaofan Huang, Lingyun Ren

Affiliation Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
⨯
Lingyun Ren ,

Contributed equally to this work with: Xiaofan Huang, Lingyun Ren

Affiliation Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
⨯
Ping Ye,

Affiliation Department of Cardiology, Central Hospital of Wuhan, Wuhan, People’s Republic of China
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Chao Cheng,

Affiliation Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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Jie Wu,

Affiliation Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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Sihua Wang,

Affiliation Department of Thoracic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
⨯
Yuan Sun,

Affiliation Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
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Zheng Liu,

Affiliation Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
⨯
Aini Xie,

Affiliation Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, Baylor College of Medicine, Houston, Texas, United States of America
⨯
Jiahong Xia

* E-mail: jiahong.xia@mail.hust.edu.cn

Affiliations Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China, Department of Cardiovascular Surgery, Central Hospital of Wuhan, Wuhan, People’s Republic of China
⨯

Peroxisome Proliferator-Activated Receptor γ Deficiency in T Cells Accelerates Chronic Rejection by Influencing the Differentiation of CD4+ T Cells and Alternatively Activated Macrophages

Xiaofan Huang,
Lingyun Ren,
Ping Ye,
Chao Cheng,
Jie Wu,
Sihua Wang,
Yuan Sun,
Zheng Liu,
Aini Xie,
Jiahong Xia

Published: November 10, 2014
https://doi.org/10.1371/journal.pone.0112953

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T cells
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Macrophages
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Cardiac transplantation
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Transplant rejection
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Cell differentiation
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