A Bumpy Ride on the Diagnostic Bench of Massive Parallel Sequencing, the Case of the Mitochondrial Genome

Kim Vancampenhout; Ben Caljon; Claudia Spits; Katrien Stouffs; An Jonckheere; Linda De Meirleir; Willy Lissens; Arnaud Vanlander; Joél Smet; Boel De Paepe; Rudy Van Coster; Sara Seneca

doi:10.1371/journal.pone.0112950

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Open Access

Peer-reviewed

Research Article

A Bumpy Ride on the Diagnostic Bench of Massive Parallel Sequencing, the Case of the Mitochondrial Genome

Kim Vancampenhout,

Affiliation Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Ben Caljon,

Affiliation Center for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Claudia Spits,

Affiliation Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Katrien Stouffs,

Affiliations Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium, Center for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
An Jonckheere,

Affiliation Department of Pediatric Neurology, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Linda De Meirleir,

Affiliations Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium, Department of Pediatric Neurology, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Willy Lissens,

Affiliations Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium, Center for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯
Arnaud Vanlander,

Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, University Hospital Ghent, Ghent University, Ghent, Belgium
⨯
Joél Smet,

Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, University Hospital Ghent, Ghent University, Ghent, Belgium
⨯
Boel De Paepe,

Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, University Hospital Ghent, Ghent University, Ghent, Belgium
⨯
Rudy Van Coster,

Affiliation Department of Pediatrics, Division of Pediatric Neurology and Metabolism, University Hospital Ghent, Ghent University, Ghent, Belgium
⨯
Sara Seneca

* E-mail: sara.seneca@uzbrussel.be

Affiliations Research Group Reproduction and Genetics (REGE), Vrije Universiteit Brussel (VUB), Brussels, Belgium, Center for Medical Genetics, UZ Brussel, Vrije Universiteit Brussel (VUB), Brussels, Belgium
⨯

A Bumpy Ride on the Diagnostic Bench of Massive Parallel Sequencing, the Case of the Mitochondrial Genome

Kim Vancampenhout,
Ben Caljon,
Claudia Spits,
Katrien Stouffs,
An Jonckheere,
Linda De Meirleir,
Willy Lissens,
Arnaud Vanlander,
Joél Smet,
Boel De Paepe

Published: November 10, 2014
https://doi.org/10.1371/journal.pone.0112950

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Mitochondrial DNA
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Polymerase chain reaction
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Mitochondria
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Nucleotide sequencing
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Nucleotides
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Genome analysis
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