A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease

Kareem L. Graham; Jian V. Zhang; Susanna Lewén; Thomas M. Burke; Ton Dang; Maria Zoudilova; Raymond A. Sobel; Eugene C. Butcher; Brian A. Zabel

doi:10.1371/journal.pone.0112925

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Open Access

Peer-reviewed

Research Article

A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease

Kareem L. Graham,

Current address: Emory University School of Medicine, Department of Physiology, Atlanta, Georgia, United States of America

Affiliation Palo Alto Veterans Institute for Research and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
⨯
Jian V. Zhang,

Current address: Laboratory for Reproductive Health, Shenzhen Institute of Advance Technology, Chinese Academy of Sciences, Shenzhen 518055, China

Affiliation Palo Alto Veterans Institute for Research and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
⨯
Susanna Lewén,

Affiliation Palo Alto Veterans Institute for Research and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
⨯
Thomas M. Burke,

Affiliation Palo Alto Veterans Institute for Research and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
⨯
Ton Dang,

Affiliation ChemoCentryx, Inc., Mountain View, California, United States of America
⨯
Maria Zoudilova,

Current address: Genentech, A Member of the Roche Group, South San Francisco, California, United States of America

Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Raymond A. Sobel,

Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Eugene C. Butcher,

Affiliation Department of Pathology, Stanford University School of Medicine, Stanford, California, United States of America
⨯
Brian A. Zabel

* E-mail: bazabel@alum.mit.edu

Affiliation Palo Alto Veterans Institute for Research and Veterans Affairs Palo Alto Health Care System, Palo Alto, California, United States of America
⨯

A Novel CMKLR1 Small Molecule Antagonist Suppresses CNS Autoimmune Inflammatory Disease

Kareem L. Graham,
Jian V. Zhang,
Susanna Lewén,
Thomas M. Burke,
Ton Dang,
Maria Zoudilova,
Raymond A. Sobel,
Eugene C. Butcher,
Brian A. Zabel

Published: December 1, 2014
https://doi.org/10.1371/journal.pone.0112925

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