Ligand Binding Reveals a Role for Heme in Translationally-Controlled Tumor Protein Dimerization

Andrew T. Lucas; Xiangping Fu; JingJing Liu; Mary K. Brannon; Jianhua Yang; Daniel G. S. Capelluto; Carla V. Finkielstein

doi:10.1371/journal.pone.0112823

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Peer-reviewed

Research Article

Ligand Binding Reveals a Role for Heme in Translationally-Controlled Tumor Protein Dimerization

Andrew T. Lucas ,

Contributed equally to this work with: Andrew T. Lucas, Xiangping Fu

Affiliations Integrated Cellular Responses Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America, Protein Signaling Domains Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Xiangping Fu ,

Contributed equally to this work with: Andrew T. Lucas, Xiangping Fu

Affiliation Integrated Cellular Responses Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
JingJing Liu,

Affiliation Integrated Cellular Responses Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
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Mary K. Brannon,

Affiliation Protein Signaling Domains Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
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Jianhua Yang,

Current address: DuPont Pioneer, 7300 NW 62nd Ave., P.O. Box 1004, Johnston, Iowa, United States of America

Affiliation Integrated Cellular Responses Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
⨯
Daniel G. S. Capelluto,

Affiliation Protein Signaling Domains Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
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Carla V. Finkielstein

* E-mail: finkielc@vt.edu

Affiliation Integrated Cellular Responses Laboratory, Virginia Bioinformatics Institute, Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America
⨯

Ligand Binding Reveals a Role for Heme in Translationally-Controlled Tumor Protein Dimerization

Andrew T. Lucas,
Xiangping Fu,
JingJing Liu,
Mary K. Brannon,
Jianhua Yang,
Daniel G. S. Capelluto,
Carla V. Finkielstein

Published: November 14, 2014
https://doi.org/10.1371/journal.pone.0112823

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Heme
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Dimerization
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Fluorescence
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Absorption spectra
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Serine proteases
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Cell binding
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Dimers
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NMR spectroscopy
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