Adipose Hypothermia in Obesity and Its Association with Period Homolog 1, Insulin Sensitivity, and Inflammation in Fat

Masaya Yamaoka; Norikazu Maeda; Yasunori Takayama; Ryohei Sekimoto; Yu Tsushima; Keisuke Matsuda; Takuya Mori; Kana Inoue; Hitoshi Nishizawa; Makoto Tominaga; Tohru Funahashi; Iichiro Shimomura

doi:10.1371/journal.pone.0112813

Loading metrics

Open Access

Peer-reviewed

Research Article

Adipose Hypothermia in Obesity and Its Association with Period Homolog 1, Insulin Sensitivity, and Inflammation in Fat

Masaya Yamaoka,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Norikazu Maeda ,

* E-mail: norikazu_maeda@endmet.med.osaka-u.ac.jp

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Yasunori Takayama,

Affiliation Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Okazaki, Aichi, 444-8787, Japan
⨯
Ryohei Sekimoto,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Yu Tsushima,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Keisuke Matsuda,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Takuya Mori,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Kana Inoue,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Hitoshi Nishizawa,

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Makoto Tominaga,

Affiliations Division of Cell Signaling, Okazaki Institute for Integrative Bioscience (National Institute for Physiological Sciences), National Institutes of Natural Sciences, Okazaki, Aichi, 444-8787, Japan, Department of Physiological Sciences, The Graduate University for Advanced Studies, Okazaki, Aichi, 444-8585, Japan
⨯
Tohru Funahashi,

Affiliations Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan, Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯
Iichiro Shimomura

Affiliation Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, 565-0871, Japan
⨯

Adipose Hypothermia in Obesity and Its Association with Period Homolog 1, Insulin Sensitivity, and Inflammation in Fat

Masaya Yamaoka,
Norikazu Maeda,
Yasunori Takayama,
Ryohei Sekimoto,
Yu Tsushima,
Keisuke Matsuda,
Takuya Mori,
Kana Inoue,
Hitoshi Nishizawa,
Makoto Tominaga

Published: November 14, 2014
https://doi.org/10.1371/journal.pone.0112813

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Adipocytes
Is the Subject Area "Adipocytes" applicable to this article?

Thanks for your feedback.
Obesity
Is the Subject Area "Obesity" applicable to this article?

Thanks for your feedback.
Adipose tissue
Is the Subject Area "Adipose tissue" applicable to this article?

Thanks for your feedback.
Body temperature
Is the Subject Area "Body temperature" applicable to this article?

Thanks for your feedback.
Hypothermia
Is the Subject Area "Hypothermia" applicable to this article?

Thanks for your feedback.
Circadian rhythms
Is the Subject Area "Circadian rhythms" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Insulin
Is the Subject Area "Insulin" applicable to this article?

Thanks for your feedback.