Hidden Disease Susceptibility and Sexual Dimorphism in the Heterozygous Knockout of Cyp51 from Cholesterol Synthesis

Monika Lewinska; Peter Juvan; Martina Perse; Jera Jeruc; Spela Kos; Gregor Lorbek; Ziga Urlep; Rok Keber; Simon Horvat; Damjana Rozman

doi:10.1371/journal.pone.0112787

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Open Access

Peer-reviewed

Research Article

Hidden Disease Susceptibility and Sexual Dimorphism in the Heterozygous Knockout of Cyp51 from Cholesterol Synthesis

Monika Lewinska,

Affiliation Center for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
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Peter Juvan,

Affiliation Center for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
⨯
Martina Perse,

Affiliation Medical Experimental Centre, Institute of Pathology, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
⨯
Jera Jeruc,

Affiliation Medical Experimental Centre, Institute of Pathology, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
⨯
Spela Kos,

Affiliations Center for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia, Institute of Oncology Ljubljana, Zaloška cesta 2, SI–1000, Ljubljana, Slovenia
⨯
Gregor Lorbek,

Affiliation Center for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
⨯
Ziga Urlep,

Affiliation Center for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
⨯
Rok Keber,

Affiliation Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230, Domžale, Slovenia
⨯
Simon Horvat,

Affiliations Department of Animal Science, Biotechnical Faculty, University of Ljubljana, Groblje 3, 1230, Domžale, Slovenia, National Institute of Chemistry, Hajdrihova 19, 1000, Ljubljana, Slovenia
⨯
Damjana Rozman

* E-mail: damjana.rozman@mf.uni-lj.si

Affiliation Center for Functional Genomics and Bio-Chips, Faculty of Medicine, University of Ljubljana, SI-1000, Ljubljana, Slovenia
⨯

Hidden Disease Susceptibility and Sexual Dimorphism in the Heterozygous Knockout of Cyp51 from Cholesterol Synthesis

Monika Lewinska,
Peter Juvan,
Martina Perse,
Jera Jeruc,
Spela Kos,
Gregor Lorbek,
Ziga Urlep,
Rok Keber,
Simon Horvat,
Damjana Rozman

Published: November 13, 2014
https://doi.org/10.1371/journal.pone.0112787

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Cholesterol
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Diet
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Trophic interactions
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Gene expression
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Lipids
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Fatty liver
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Heterozygosity
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Chemical synthesis
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