Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling

Eduardo Fuentes; Jaime Pereira; Diego Mezzano; Marcelo Alarcón; Julio Caballero; Iván Palomo

doi:10.1371/journal.pone.0112741

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Peer-reviewed

Research Article

Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling

Eduardo Fuentes ,

* E-mail: ipalomo@utalca.cl (IP); edfuentes@utalca.cl (EF)

Affiliations Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile, Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, Talca, Chile
⨯
Jaime Pereira,

Affiliation Department of Hematology-Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Diego Mezzano,

Affiliation Department of Hematology-Oncology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
⨯
Marcelo Alarcón,

Affiliations Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile, Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, Talca, Chile
⨯
Julio Caballero,

Affiliation Center for Bioinformatics and Molecular Simulations, Faculty of Engineering in Bioinformatics, Universidad de Talca, Talca, Chile
⨯
Iván Palomo

* E-mail: ipalomo@utalca.cl (IP); edfuentes@utalca.cl (EF)

Affiliations Department of Clinical Biochemistry and Immunohematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile, Centro de Estudios en Alimentos Procesados (CEAP), CONICYT-Regional, Gore Maule, Talca, Chile
⨯

Inhibition of Platelet Activation and Thrombus Formation by Adenosine and Inosine: Studies on Their Relative Contribution and Molecular Modeling

Eduardo Fuentes,
Jaime Pereira,
Diego Mezzano,
Marcelo Alarcón,
Julio Caballero,
Iván Palomo

Published: November 13, 2014
https://doi.org/10.1371/journal.pone.0112741

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Adenosine
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Inosine
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Platelets
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Platelet aggregation
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Platelet activation
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Collagens
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Antiplatelet therapy
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