Fusarochromanone Induces G1 Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells

Ying Gu; Xin Chen; Chaowei Shang; Karnika Singh; Mansoureh Barzegar; Elahe Mahdavian; Brian A. Salvatore; Shanxiang Jiang; Shile Huang

doi:10.1371/journal.pone.0112641

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Open Access

Peer-reviewed

Research Article

Fusarochromanone Induces G₁ Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells

Ying Gu,

Affiliations Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, P. R. China, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Xin Chen,

Affiliations Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, P. R. China, Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯
Chaowei Shang,

Affiliations Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Karnika Singh,

Affiliation Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Mansoureh Barzegar,

Affiliation Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
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Elahe Mahdavian,

Affiliation Department of Chemistry and Physics, Louisiana State University, Shreveport, Louisiana, United States of America
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Brian A. Salvatore,

Affiliation Department of Chemistry and Physics, Louisiana State University, Shreveport, Louisiana, United States of America
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Shanxiang Jiang ,

* E-mail: shuan1@lsuhsc.edu (SH); nauvy@sina.com (SJ)

Affiliation Laboratory of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, P. R. China
⨯
Shile Huang

* E-mail: shuan1@lsuhsc.edu (SH); nauvy@sina.com (SJ)

Affiliations Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America
⨯

Fusarochromanone Induces G₁ Cell Cycle Arrest and Apoptosis in COS7 and HEK293 Cells

Ying Gu,
Xin Chen,
Chaowei Shang,
Karnika Singh,
Mansoureh Barzegar,
Elahe Mahdavian,
Brian A. Salvatore,
Shanxiang Jiang,
Shile Huang

Published: November 10, 2014
https://doi.org/10.1371/journal.pone.0112641

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Apoptosis
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Cell proliferation
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Cyclins
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Cell cycle and cell division
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Cell cycle inhibitors
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HEK 293 cells
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Kinase inhibitors
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