Celastrol Stimulates Hypoxia-Inducible Factor-1 Activity in Tumor Cells by Initiating the ROS/Akt/p70S6K Signaling Pathway and Enhancing Hypoxia-Inducible Factor-1α Protein Synthesis

Open Access

Peer-reviewed

Research Article

Xiaoxi Han ,

Contributed equally to this work with: Xiaoxi Han, Shengkun Sun

Affiliation Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China
⨯
Shengkun Sun ,

Contributed equally to this work with: Xiaoxi Han, Shengkun Sun

Affiliation Department of Urology, The General Hospital of PLA, Beijing, China
⨯
Ming Zhao,

Affiliation Department of Cognitive Science, Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing, China
⨯
Xiang Cheng,

Affiliation Department of Cognitive Science, Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing, China
⨯
Guozhu Chen,

Affiliation Department of Cognitive Science, Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing, China
⨯
Song Lin,

Affiliation Department of Cognitive Science, Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing, China
⨯
Yifu Guan ,

* E-mail: yfguan@mail.cmu.edu.cn (YG); yuxd@bmi.ac.cn (XY)

Affiliation Department of Biochemistry and Molecular Biology, China Medical University, Shenyang, China
⨯
Xiaodan Yu

* E-mail: yfguan@mail.cmu.edu.cn (YG); yuxd@bmi.ac.cn (XY)

Affiliation Department of Cognitive Science, Institute of Basic Medical Sciences, Cognitive and Mental Health Research Center, Beijing, China
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Hypoxia
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Apoptosis
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DNA transcription
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Small interfering RNA
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Cell death
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Cytotoxicity
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Flow cytometry
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