Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy

Kyoko Yoshida; Hongfeng Jiang; MiJung Kim; Joy Vink; Serge Cremers; David Paik; Ronald Wapner; Mala Mahendroo; Kristin Myers

doi:10.1371/journal.pone.0112391

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Peer-reviewed

Research Article

Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy

Kyoko Yoshida,

Affiliation Department of Mechanical Engineering, Columbia University, New York, New York, United States of America
⨯
Hongfeng Jiang,

Affiliations Department of Medicine, Columbia University Medical Center, New York, New York, United States of America, Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, New York, United States of America
⨯
MiJung Kim,

Affiliation Department of Opthalmology, Columbia University Medical Center, New York, New York, United States of America
⨯
Joy Vink,

Affiliation Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America
⨯
Serge Cremers,

Affiliations Department of Medicine, Columbia University Medical Center, New York, New York, United States of America, Irving Institute for Clinical and Translational Research, Columbia University Medical Center, New York, New York, United States of America
⨯
David Paik,

Affiliation Department of Opthalmology, Columbia University Medical Center, New York, New York, United States of America
⨯
Ronald Wapner,

Affiliation Department of Obstetrics and Gynecology, Columbia University Medical Center, New York, New York, United States of America
⨯
Mala Mahendroo,

Affiliation Department of Obstetrics and Gynecology, UT Southwestern Medical Center, Dallas, Texas, United States of America
⨯
Kristin Myers

* E-mail: kmm2233@columbia.edu

Affiliation Department of Mechanical Engineering, Columbia University, New York, New York, United States of America
⨯

Quantitative Evaluation of Collagen Crosslinks and Corresponding Tensile Mechanical Properties in Mouse Cervical Tissue during Normal Pregnancy

Kyoko Yoshida,
Hongfeng Jiang,
MiJung Kim,
Joy Vink,
Serge Cremers,
David Paik,
Ronald Wapner,
Mala Mahendroo,
Kristin Myers

Published: November 14, 2014
https://doi.org/10.1371/journal.pone.0112391

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Collagens
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Mechanical properties
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Stiffness
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Pregnancy
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Cervix
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Tissue mechanics
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Linear regression analysis
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