Dll4 Blockade Potentiates the Anti-Tumor Effects of VEGF Inhibition in Renal Cell Carcinoma Patient-Derived Xenografts

Kiersten Marie Miles; Mukund Seshadri; Eric Ciamporcero; Remi Adelaiye; Bryan Gillard; Paula Sotomayor; Kristopher Attwood; Li Shen; Dylan Conroy; Frank Kuhnert; Alshad S. Lalani; Gavin Thurston; Roberto Pili

doi:10.1371/journal.pone.0112371

Loading metrics

Open Access

Peer-reviewed

Research Article

Dll4 Blockade Potentiates the Anti-Tumor Effects of VEGF Inhibition in Renal Cell Carcinoma Patient-Derived Xenografts

Kiersten Marie Miles,

Affiliation Genitourinary Program, Roswell Park Cancer Institute, Buffalo, New York, United States of America
⨯
Mukund Seshadri,

Affiliation Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America
⨯
Eric Ciamporcero,

Affiliation Medicine and Experimental Oncology, University of Turin, Turin, Italy
⨯
Remi Adelaiye,

Affiliation Department of Cancer Pathology & Prevention, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America
⨯
Bryan Gillard,

Affiliation Department of Pharmacology & Therapeutics, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America
⨯
Paula Sotomayor,

Affiliation Department of Molecular and Cellular Biology, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America
⨯
Kristopher Attwood,

Affiliation Department of Biostatistics & Bioinformatics, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America
⨯
Li Shen,

Affiliation Genitourinary Program, Roswell Park Cancer Institute, Buffalo, New York, United States of America
⨯
Dylan Conroy,

Affiliation Genitourinary Program, Roswell Park Cancer Institute, Buffalo, New York, United States of America
⨯
Frank Kuhnert,

Affiliation Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America
⨯
Alshad S. Lalani,

Affiliation Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America
⨯
Gavin Thurston,

Affiliation Regeneron Pharmaceuticals, Inc., Tarrytown, New York, United States of America
⨯
Roberto Pili

* E-mail: Roberto.Pili@RoswellPark.org

Affiliations Genitourinary Program, Roswell Park Cancer Institute, Buffalo, New York, United States of America, Department of Cancer Pathology & Prevention, Roswell Park Cancer Institute Division, University at Buffalo, Buffalo, New York, United States of America
⨯

Dll4 Blockade Potentiates the Anti-Tumor Effects of VEGF Inhibition in Renal Cell Carcinoma Patient-Derived Xenografts

Kiersten Marie Miles,
Mukund Seshadri,
Eric Ciamporcero,
Remi Adelaiye,
Bryan Gillard,
Paula Sotomayor,
Kristopher Attwood,
Li Shen,
Dylan Conroy,
Frank Kuhnert

Published: November 13, 2014
https://doi.org/10.1371/journal.pone.0112371

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Renal cancer
Is the Subject Area "Renal cancer" applicable to this article?

Thanks for your feedback.
Renal cell carcinoma
Is the Subject Area "Renal cell carcinoma" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Breast cancer
Is the Subject Area "Breast cancer" applicable to this article?

Thanks for your feedback.
Magnetic resonance imaging
Is the Subject Area "Magnetic resonance imaging" applicable to this article?

Thanks for your feedback.
Nasopharyngeal carcinoma
Is the Subject Area "Nasopharyngeal carcinoma" applicable to this article?

Thanks for your feedback.