Cigarette Smoking Promotes Inflammation in Patients with COPD by Affecting the Polarization and Survival of Th/Tregs through Up-Regulation of Muscarinic Receptor 3 and 5 Expression

Ming-Qiang Zhang; Yong Wan; Yang Jin; Jian-Bao Xin; Jian-Chu Zhang; Xian-Zhi Xiong; Long Chen; Gang Chen

doi:10.1371/journal.pone.0112350

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Research Article

Cigarette Smoking Promotes Inflammation in Patients with COPD by Affecting the Polarization and Survival of Th/Tregs through Up-Regulation of Muscarinic Receptor 3 and 5 Expression

Ming-Qiang Zhang ,

Contributed equally to this work with: Ming-Qiang Zhang, Yong Wan

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Yong Wan ,

Contributed equally to this work with: Ming-Qiang Zhang, Yong Wan

Affiliation Department of Respiratory and Critical Care Medicine WUHAN NO. 1 HOSPITAL, Wuhan, China
⨯
Yang Jin,

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jian-Bao Xin,

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Jian-Chu Zhang,

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Xian-Zhi Xiong ,

* E-mail: xxz0508@hust.edu.cn

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Long Chen,

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯
Gang Chen

Affiliation Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
⨯

Cigarette Smoking Promotes Inflammation in Patients with COPD by Affecting the Polarization and Survival of Th/Tregs through Up-Regulation of Muscarinic Receptor 3 and 5 Expression

Ming-Qiang Zhang,
Yong Wan,
Yang Jin,
Jian-Bao Xin,
Jian-Chu Zhang,
Xian-Zhi Xiong,
Long Chen,
Gang Chen

Published: November 6, 2014
https://doi.org/10.1371/journal.pone.0112350

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