Inhibition of Aurora Kinase B Is Important for Biologic Activity of the Dual Inhibitors of BCR-ABL and Aurora Kinases R763/AS703569 and PHA-739358 in BCR-ABL Transformed Cells

Anna L. Illert; Anna K. Seitz; Christoph Rummelt; Stefanie Kreutmair; Richard A. Engh; Samantha Goodstal; Christian Peschel; Justus Duyster; Nikolas von Bubnoff

doi:10.1371/journal.pone.0112318

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Research Article

Inhibition of Aurora Kinase B Is Important for Biologic Activity of the Dual Inhibitors of BCR-ABL and Aurora Kinases R763/AS703569 and PHA-739358 in BCR-ABL Transformed Cells

Anna L. Illert ,

* E-mail: Lena.Illert@uniklinik-freiburg.de

¶ALI and AKS are joint first authors on this work.

Affiliation Clinic for Internal Medicine 1, Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, 79106 Freiburg, Germany
⨯
Anna K. Seitz ,

¶ALI and AKS are joint first authors on this work.

Affiliation Department of Internal Medicine III, Technical University of Munich, 81675 Munich, Germany
⨯
Christoph Rummelt,

Affiliation Clinic for Internal Medicine 1, Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, 79106 Freiburg, Germany
⨯
Stefanie Kreutmair,

Affiliation Clinic for Internal Medicine 1, Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, 79106 Freiburg, Germany
⨯
Richard A. Engh,

Affiliation The Norwegian Structural Biology Centre, Departments of Chemistry and Pharmacy, University of Tromsø, Tromsø, Norway
⨯
Samantha Goodstal,

Affiliation EMD-Serono Research and Development Institute, Inc., Billerica, Massachusetts, United States of America
⨯
Christian Peschel,

Affiliation Department of Internal Medicine III, Technical University of Munich, 81675 Munich, Germany
⨯
Justus Duyster ,

¶‡ JD and NVB are joint last authors on this work.

Affiliation Clinic for Internal Medicine 1, Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, 79106 Freiburg, Germany
⨯
Nikolas von Bubnoff

¶‡ JD and NVB are joint last authors on this work.

Affiliation Clinic for Internal Medicine 1, Hematology, Oncology and Stem Cell Transplantation, Freiburg University Medical Center, 79106 Freiburg, Germany
⨯

Inhibition of Aurora Kinase B Is Important for Biologic Activity of the Dual Inhibitors of BCR-ABL and Aurora Kinases R763/AS703569 and PHA-739358 in BCR-ABL Transformed Cells

Anna L. Illert,
Anna K. Seitz,
Christoph Rummelt,
Stefanie Kreutmair,
Richard A. Engh,
Samantha Goodstal,
Christian Peschel,
Justus Duyster,
Nikolas von Bubnoff

Published: November 26, 2014
https://doi.org/10.1371/journal.pone.0112318

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