Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2

Huawang Sun; Guo Li; Wenjuan Zhang; Qi Zhou; Yena Yu; Ying Shi; Stefan Offermanns; Jianxin Lu; Naiming Zhou

doi:10.1371/journal.pone.0112310

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Open Access

Peer-reviewed

Research Article

Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2

Huawang Sun ,

Contributed equally to this work with: Huawang Sun, Guo Li

Affiliation Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Guo Li ,

Contributed equally to this work with: Huawang Sun, Guo Li

Affiliations College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, China, Institute of Aging Research, Hangzhou Normal University, Hangzhou, Zhejiang, China
⨯
Wenjuan Zhang,

Affiliation Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Qi Zhou,

Affiliation Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Yena Yu,

Affiliation Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Ying Shi,

Affiliation College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, China
⨯
Stefan Offermanns,

Affiliation Department of Pharmacology, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany
⨯
Jianxin Lu ,

* E-mail: znm2000@yahoo.com (NZ); jxlu313@163.com (JL)

Affiliation Zhejiang Provincial Key Laboratory of Medical Genetics, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang, China
⨯
Naiming Zhou

* E-mail: znm2000@yahoo.com (NZ); jxlu313@163.com (JL)

Affiliation College of Life Sciences, Zijingang Campus, Zhejiang University, Hangzhou, Zhejiang, China
⨯

Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2

Huawang Sun,
Guo Li,
Wenjuan Zhang,
Qi Zhou,
Yena Yu,
Ying Shi,
Stefan Offermanns,
Jianxin Lu,
Naiming Zhou

Published: November 6, 2014
https://doi.org/10.1371/journal.pone.0112310

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Niacin
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AKT signaling cascade
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Transactivation
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Phosphorylation
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Macrophages
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Transfection
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Protein kinase signaling cascade
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Blood plasma
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