Promoter Methylation-Mediated Silencing of β-Catenin Enhances Invasiveness of Non-Small Cell Lung Cancer and Predicts Adverse Prognosis

Yuan Miao; Liang Wang; Xiupeng Zhang; Xiaohan Xu; Guiyang Jiang; Chuifeng Fan; Yang Liu; Xuyong Lin; Juanhan Yu; Yong Zhang; Enhua Wang

doi:10.1371/journal.pone.0112258

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Open Access

Peer-reviewed

Research Article

Promoter Methylation-Mediated Silencing of β-Catenin Enhances Invasiveness of Non-Small Cell Lung Cancer and Predicts Adverse Prognosis

Yuan Miao,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Liang Wang,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Xiupeng Zhang,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Xiaohan Xu,

Affiliation 96K Seven-year Program of Medicine, China Medical University, Shenyang, China
⨯
Guiyang Jiang,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Chuifeng Fan,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Yang Liu,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Xuyong Lin,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Juanhan Yu,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Yong Zhang,

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯
Enhua Wang

* E-mail: wangeh@hotmail.com

Affiliation Department of Pathology, The First Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China
⨯

Promoter Methylation-Mediated Silencing of β-Catenin Enhances Invasiveness of Non-Small Cell Lung Cancer and Predicts Adverse Prognosis

Yuan Miao,
Liang Wang,
Xiupeng Zhang,
Xiaohan Xu,
Guiyang Jiang,
Chuifeng Fan,
Yang Liu,
Xuyong Lin,
Juanhan Yu,
Yong Zhang

Published: November 14, 2014
https://doi.org/10.1371/journal.pone.0112258

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Non-small cell lung cancer
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Methylation
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Cancer treatment
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DNA methylation
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Lung and intrathoracic tumors
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Wnt signaling cascade
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Gastric cancer
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