NPRL-Z-1, as a New Topoisomerase II Poison, Induces Cell Apoptosis and ROS Generation in Human Renal Carcinoma Cells

• Szu-Ying Wu,

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Shiow-Lin Pan,

  Affiliation The Ph.D. program for Cancer Biology and Drug Discovery, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan

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• Zhi-Yan Xiao,

  Affiliation Beijing Key Laboratory of Active Substance Discovery and Drug ability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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• Jui-Ling Hsu,

  Affiliation School of Pharmacy, College of Medicine, National Taiwan University, Taipei, Taiwan

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• Mei-Chuan Chen,

  Affiliations The Ph.D. Program for the Clinical Drug Discovery from Botanical Herbs, College of Pharmacy, Taipei Medical University, Taipei, Taiwan, Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan

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• Kuo-Hsiung Lee,

  Affiliations Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung, Taiwan

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• Che-Ming Teng

  * E-mail: cmteng@ntu.edu.tw

  Affiliation Pharmacological Institute, College of Medicine, National Taiwan University, Taipei, Taiwan

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